Phycotoxins: Chemistry and Biochemistry presents the most updated information available on phycotoxins. Major emphases are given to chemistry and biochemistry, while minor emphases are given to the aspects of origin, toxicology, or analytical methodology. The book discusses 16 phycotoxins, 7 on those affecting the nervous systems, 4 affecting other body systems; and 4 with undefined targets.
An alphabetical listing of toxins presented includes: Azaspiracids; Brevetoxins; Cyanobacterial toxins; Domoic acid; Gambierols; Gymnodimines, prorocentrolides, spirolides, pinnatoxins and cyclic imines in general; Maitotoxin; Okadaic acid and dinophysistoxins; Palytoxins and ostreocins; Pectenotoxins; Polycavernosides; and Yessotoxins. In addition, several mechanistic aspects of newer or emerging toxins are covered such as amphidinols or gymnocine. Information presented and coverage of each toxin follows the following distribution: background and toxicology (10%); chemistry, biochemistry and metabolism (75%); mechanism of action (10%); and analytical methodology (5%).
The detailed information on chemistry in Phycotoxins: Chemistry and Biochemistry provides investigators, regulators, food technologists and toxicologists an updated basis on which research in other areas such as toxicology, mechanism of action, analytical methodology, pharmacology can be successfully developed and expanded.
Table of Contents:
1. Gambierols
2. Brevetoxins: Structure, Toxicology and Origin
3. Chemistry of Maitotoxin
4. Biochemistry of Maitotoxin
5. The Chemistry of Palytoxins and Ostreocins
6. Biochemistry of Palytoxins and Ostreocins
7. Chemistry of Cyanobacterial Neurotoxins - Anatoxin-a: Synthetic Approaches
8. Anatoxin-a and Analogues: Discovery, Distribution and Toxicology
9. Pectenotoxins
10. Chemistry, Orgins and Distribution of Yessotoxin and it's Analogues
11. Pharmacology of Yessotoxin
12. Chemistry of Diarrhetic Shellfish Poisoning Toxins
13. The Molecular and Integrative Basis to Domoic Acid Toxicity
14. Hepatotoxic Cyanobacteria
15. Polycavernosides
16. Structural Assignment and Total Synthesis of Azaspiracid-1
17. Biochemistry of Azaspiracid Poisoning Toxins
18. The Cyclic Imines: An Insight into this Emerging Group of Bioactive Marine Toxins
Edited by Luis Botana
Hardcover, 400 pages
2007
