Three trials were performed to better understand how soy processed in different ways impacts the growth, feed conversion ratio, and health of the Florida pompano (Trachinotus carolinus). First t wo growout trials were performed to evaluate the efficacy of an open soy-based diet in comparison to a commercially produced, fishmeal-based diet. Trial one utilized 6 replicate s and was terminated after 42 days of growout. Overall biomass (p=0.026), weight gain (p=0.006), and FCR (p =0.015) being significantly different between both treatments, with r esults showing overall preference for commercially produced fishmeal diet over the soy-based diet. The second trial was run over the course of 56 days, and upon termination there were no statistically significant differences due to diets. Histological samples taken upon termination of distal intestine showed no statistical differences in symptoms indicative of soy -induced enteritis (lamina propria thickness, goblet cell frequency, central stroma widening, and vacuolization) between the practical soy diet or the commercial fishmeal diet. To improve soy-based feed formulations we evaluated soy-based ingredients processed under different conditions. Nine experimental diets with varying soy sources were formulated in combination with 14% poultry by product meal and 6% corn protein concentrate and designed to be iso-nitrogenous and isolipidic at 40% protein and 8% lipid. A basal diet comprised of 49.97% solvent extracted soybean meal (SBM) was compared with diets containing low oligosaccharide soybean meal (SBM-LO), soy protein concentrate (SPC), fermented soybean meal (Fer-SBM), and expeller extruded soybean meal (EE-SBM) at varying levels of replacement of solvent extracted soybean meal. J uvenile Florida pompano (4.82 ± 0.08 grams) were offered randomly assigned diets in quadruplicate for 76 days. Upon termination, there were no significant differences in weight (p=0.493), survival (p=0.925), or FCR (p=0.874) in fish offered any of the experimental diets. Histological analysis of distal intestine samples showed no statistical differences in lamina propria thickness, goblet cell frequency, or vacuolization, however there was significant differences in lamina propria thickness between samples offered SPC at 100% replacement and Fer-SBM at 50% replacement. Based on the current study, it can be inferred that Florida pompano offered a soy-based diet show no adverse effects in terms of growth or health when compared to a diet primarily composed of fishmeal . Despite no significant differences between soy sources , fish offered EE-SBM at 25% replacement performed best , having the highest overall weight and percent weight gain as well as having the lowest feed conversion rate.