This study was conducted to investigate the effects of replacing dietary solvent extract soybean meal (SBM) with low oligosaccharide soybean meal (L-SBM) or enzyme treated soybean meal (E-SBM) on the growth performance and body composition of juvenile largemouth bass (Micropterus nigricans). Nine isonitrogenous (40%) and isolipid (8%) treatment diets were designed for juvenile largemouth bass. The basal diet contained 50% SBM as the primary protein source. The SBM was incrementally replaced on an isonitrogenous basis with 40%, 60%, 80% and 100% using L-SBM or E-SBM. Each aquarium was stocked with fifteen 8.55±0.18g juvenile largemouth bass and the fish were randomly assigned to the above nine treatment diets (six replicates of Basal, LSBM100% and ESBM100%; four replicates of the other six treatments). The fish were fed twice daily for six weeks. The mean weight and weight gain (g) of the fish offered the diet containing 60% and 80% of E-SBM were significantly higher than those of fish fed the other treatment diets. The mean weight and weight gain (g) of the fish fed with LSBM40%, LSBM60%, LSBM80%, LSBM100%, ESBM40% and ESBM100% diets were not significantly different. The fish fed with the basal diet had significantly lower mean weight and weight gain(g) than those fish fed the other diets. No significant differences were found in weight gain (%), PER and survival between the fish fed the nine diets. Results demonstrate that L-SBM and E-SBM are two potential ingredients which could be used in juvenile northern largemouth bass diets as a primary protein source without negative effect on growth performance.