Anthropogenic changes are significantly impacting animal physiology, altering the ways in which we produce seafood—particularly when, where, and how it is done. Despite extensive research efforts, most studies have focused on short-term climate change experiments, leaving critical knowledge gaps about the medium- and long-term effects on production practices. We will overview several ongoing projects that aim to address these gaps, with a particular focus on commercial sea urchin production. As wild fisheries decline, aquaculture has emerged as a promising alternative for sustaining the sector. We will present work on multigenerational breeding and high-frequency field sampling to explore how ocean acidification and warming affect sea urchin physiology and reproduction, key factors influencing production output and the timing of practices. Additionally, we will share the latest findings from a high-resolution species distribution model (SDM), used to map historical species distributions and forecast future shifts under ongoing anthropogenic changes which can inform future aquaculture siting. While this research focusses on sea urchin species produced in the Atlantic, these insights have broad implications for other commercially important species and production practices in both aquaculture and fisheries.