As one of the most successful and established U.S. aquaculture sectors, the U.S. catfish industry has experienced notable fluctuations over the years. While there has been an overall upward trend in the farmer’s price and production efficiency due to technological advancements and effective production strategies, the farming area has witnessed a noticeable decline over the last two decades. Yet the production volumes have stabilized over the last decade. This study investigated the factors influencing domestic catfish supply from farms. Using 25 years of supply data (Figure 1), this study focused on establishing a relationship between the round weight processed and various factors including feed prices, the area under farming, and macroeconomic indicators like soybean and corn mill prices, imports, population, inflation, and unemployment rates. This paradoxical situation called for a detailed study. A Trans-log generalized regression model indicate d an inverse relationship between feed prices and the quantity of catfish supplied. Conversely, a positive relationship exists between the area under production and the quantity of catfish supplied, suggesting that increased production area boosted catfish production. Macroeconomic factors played a significant role as well; with population growth and inflation positively influencing the quantity supplied, as producers increase output to meet rising demand and counter inflationary pressures. The findings highlighted the influence of various micro and macro-economic factors that shaped this vital U.S. aquaculture sector.