Intensive farming increases stress on the host and introduces new diseases or pathogens to emerge. This scenario has increased the usage of antibiotics in aquaculture worldwide. Antimicrobial drugs can be very useful in combating pathogenic bacterial infections in humans and animals. However, it has negative implications as it increases the number of anti-microbial resistance (AMR) micro-organisms that can spread from animal to human by direct exposure or consumption of food containing AMR. There is a tight relationship between microalgae and bacteria both as agonist & antagonistic through the release of diverse compounds important for various metabolic functions. One of the mechanisms is through the interference of bacterial cell-to-cell communication or quorum sensing (QS). In this study, the effects of microalgae as quorum sensing inhibitor (QSI) were investigated. This was first done through screening of the algal extracts with different QS reporter strain followed by compound identification through LCMS metabolomics . As quorum sensing has been shown to regulate the virulence of aquaculture pathogens, inhibition of QS from algae could be an interesting option for prevention of bacterial diseases and improves production in larviculture.