Schizochytrium sp. (Sch), as a microalgae, has attracted considerable attention as a feed ingredient or additive due to its high lipid and DHA levels. T his study was performed to investigate the effect of feeding Sch-enriched Brachionus rotundiformis (Exp-1) and Artemia nauplii (Exp-2) on the growth and immunity of the Pacific white shrimp . For Exp-1, a non-enriched Brachionus rotundiformis control group (Con) and four other rotifer groups enriched with Sch, Sch+0.1% taurine, Sch+0.1% inosine monophosphate (IMP) and chlorella powder (designate d as Sch, SchT, SchI and CP, respectively) were used. Four replicate groups of early-larval stage shrimp (body length: 0.67±0.03 mm) fed one of the diets three times a day for 9 days . At the end of the trial, final length, length gain, survival, t he expression of LGBP1 (lipopolysaccharide and β-1,3-glucan-binding protein) and penaeidin-3a genes were significantly improved in shrimp fed Sch, SchI and SchT diets compared to those fed Con and CP diets (P<0.05) . Lysozyme and crustin gene expressions were significantly upregulated in all the enriched groups compared to the Con group (P<0.05) . Based on Exp-1 results, the growth performance, survival and immune responses of the early-l arval shrimp can be improved by feeding Sch- enriched rotifer and its utilization could be increased by adding taurine or IMP. For Exp-2 , a non-enriched Artemia nauplii control group and four other Artemia nauplii groups enriched with the same Sch , SchT, SchI and CP were used . Four replicate groups of post-larvae shrimp (Body length: 9.12±0.38 mm) fed one of the diets three times a day for 12 days. Final body weight and weight gain were significantly higher in Sch groups than in Con group (P<0.05). Length gain and gene expression of crustin and LGBP1 were significantly increased in SchT and SchI groups than in Con and CP groups (P<0.05) . Lysozyme gene expression was significantly upregulated in SchT group than in Con and CP groups (P<0.05) . Gene expression of penaeidin-3a was significantly upregulated in SchI group than in Con and CP groups (P<0.05) . Based on Exp-2 results, the findings indicate t hat feeding Sch-enriched Artemia nauplii could promote the growth and non-specific immunity of Pacific white shrimp post-larvae.