Stress is the pressure that happen in shrimp that make them fall sick and later outbreak with disease that cause farmer losses all their investment. Shrimp is also a smart biological being; they also have it own mechanism to counter stress and has the ability to supress pathogen like virus and bacteria. One or two stresses, not a problem for the shrimp to counter it but what happen the stress prolong and with additional stress build up, for sure will break the shrimp immunity and outbreak pursue. Combination of stress factor like C:N ratio, vibrio, minerals, feed quality and plankton will break the shrimp immune respond beyond no return. When w e understand how to overcome the stresses, we can have a better chance to harvest profitably .