A 50-day feeding trial was conducted to assess the effects of dietary lecithin addition to increase the replacement of soybean meal with fermented copra meal (FCM) in the diet of a saline tolerant juvenile Nile tilapia strain, A factorial experiment was conducted comprising seven iso-nitrogenous and isolipidic diets. Two dietary levels of soybean lecithin at 0% and 3% comprises the first independent factor and soybean meal replacement levels (50%, 75 %, and 100%) with FCM as the 2nd experimental factor. Juvenile tilapia (size: 0.87 ± 0.21 g) were group into triplicate tanks per treatment with 10 fish per tank and fed the experimental diets for 50 days. Results indicate a significantly higher (P < 0.05) percent weight gain in Trt 6 (100% FCM, 3% lecithin) and the positive control. Results showed that the addition of 3 % dietary soybean lecithin, promoted complete replacement of soybean meal with FCM without significant reduction on feed utilization, blood biochemistry, villi length, enterocyte height, muscle fiber count, serum transaminase levels, digestive enzyme activity and fatty acid composition of the tilapia. Other parameters measured, such as protein retention, somatic indices, and recovery rate from air exposure test were not influenced by the treatment. Moreover, a substituted 100% FCM and 3% SBL diet could be considered viable FCM and lecithin replacement level for saline tolerant strain Nile tilapia juveniles.