Spiny Sand Lobster (Panulirus homarus) is one of the lobster species that has hight price in the local and international market and is economically valueable.The objective of this study is to know the biologically performance the Lobster such as; the survival rate, Specific daily growth rate, feed conversion ratio, and physiological responses. These studies were done with three different treatments of stocking density at 7 m water depth. The observation were treatment A: 10 lobster/m²; treatment B : 15 lobster/m²; and treatment C : 20 lobster/m². The design of study was completely randomized design with 3 treatments and 3 replicates. The results of the study showed that there were not significant in term of food conversion ratio and daily specific growth rate as well as weight gain but was significant in term of survival rate between both treatments A (91,50 ± 0,25 %) and B (93,30 ± 0,51 %) with treatment C (86,05 ± 0,45 %) (Table 1). Physiologyical response (Table 2) between treatment A and B in term of THC hemolymph was not significant but both treatment A and B was significant with treatmen C. In term of glucose hemolymph treatment A was significant with treatment C but not with treatment B.