Recently, the application of nanoparticles (NPs) in aquaculture is increasing. Metal NPs such as iron oxide nanoparticles are often made of one metal, metal oxides, or a combination of different metals through green or chemical synthesis methods. The application of NPs in aquaculture can vary from culturing species to environment. NPs are used to improve fish growth and their health to increase aquaculture production. Furthermore, NPs also used for wastewater treatment in aquaculture to reduce eutrophication. We reviewed that the ways of NPs used in aquaculture, which can be very different: some are directly added as feed addictive, and some are added in water media for treatment purposes. In this review, we explore the influence of NPs as dietary supplementation on physiological changes: histological changes, hematology, and biochemical changes in fish, their limitations, and the type of NPs used. Additionally, it gives a brief idea about NPs used in fish diseases and traditional ways for controlling pathogens. On the other hand, this review provides knowledge on application of NPs in aquaculture management.