Heavy metal pollution is a growing environmental concern that can have serious health consequences for hum ans and wildlife. Fish are particularly vulnerable to heavy metal contamination as they can accumulate toxins in their tissues over time. This has led to increased interest in the assessment of heavy metals in fish tissues as a means of monitoring ecosystem health and human exposure risks. This study assessed the heavy metal concentrations in African Snakehead (Parachanna obscura ) from Alape River, Igbokoda in Ilaje Local Government Area of Ondo State, South Western, Nigeria. The heavy metal concentrations were in the gills, intestine, and trunk of the fish. Results shows higher concentrations of heavy metals were generally found in the gills and intestine over the months. Iron recorded the highest metal found in the fish organs and Cadmium the lowest. The hierarchy of the measured concentration level (mg/kg) of the metals was as follows: Fe (2.43mg/kg) > Ni (1.14 mg/kg) > Mn (0.45 mg/kg) > Cu (0.31 mg/kg) > Pb (0.06 mg/kg) > Cd (0.05mg/kg). The range values for Nickel were beyond the permissible limits of WHO. The fish show negative allometric growth as ’b’ values were less than 3. The condition factor (K) values for all samples of Parachanna obscura ranged between 1.13 and 3.78 with total mean value of 1.96±0.24. Continued monitoring of heavy metal levels in fish tissues is necessary to identify trends and assess the effectiveness of mitigation measures in reducing contamination levels. The fi ndings suggest that African Snakehead Parachanna obscura from Alape River can be consumed safely without posing significant health risks.