Quantifying the economic loss associated with any aquatic diseases is often confounded due to coinfections and/or comorbidity . Most estimations of economic losses from diseases include calculating revenue losses or the value of lost production . The lack of accounting for true costs results in spurious extrapolations of estimated loss values. The proper economic analytical method would be to estimate the loss of “profits” due to disease which includes a detailed estimation of cost and returns in the presence and absence of disease . Edwardsiellosis of catfish caused by E. ictaluri and E. piscicida remains one of the most significant diseases in U.S. catfish aquaculture . Economic losses related to this disease are currently unknown. This work sheds light on the losses associated with E. ictaluri and E. piscicida in catfish aquaculture. The robust economic approach employed is grounded i n farm-level production data and long-term disease trends in the industry. Direct farm-level economic losses from Edwardsiellosis ranged from -$3,485 /ha to -$13,320/ha causing industrywide economic losses of -$5.2 to -$17.6 million/year. The lost revenue due to Edwardsiellosis ranged from -$8.4 to -$24.8 million/year causing a negative economic impact of -$15.5 to -$45.9 million per year. The economic losses and negative impacts of Edwardsiellosis are relatively greater on the foodfish sector compared to the fingerling sector. This work provides a platform for a more accurate estimation of the true economic impacts of diseases for aquaculture sectors for which commercial farm data is available.