Fish farming is growing faster than other animal protein producing sectors and will play a significant role in global food security. Therefore, it is utmost important to increase both fish production sustainability and economic viability. The use of renewable alternative ingredients, such as plant-based feedstuffs , can improve fish farming sustainability and potentially reduce production costs. Corn fermented protein (CFP) is a co-product of the ethanol industry and is considered a promising feedstuff to partially replace soybean meal (SB M) and other protein feedstuffs in aquafeeds. In the present study, a feeding trial w as conducted to evaluate the growth performance of juvenile tilapia Oreochromis niloticus fed diets in which CFP was substituted primarily for SBM. A r eference diet was formulated to contain ~45 % crude protein contributed by dehulled, solvent-extracted SBM (25% by weight) , poultry byproduct meal (14% by weight), hydrolyzed feather meal (6% by weight) , and menhaden fishmeal (5% by weight) . Five isonitrogenous experimental diets were prepared by primarily replacing SBM in the Reference diet with CFP at 10, 15, 20, 25, and 30%, respectively. Lysine (Lys) was supplemented in all diets to the established requirement level . Diets were fed to quadruplicate groups of juvenile fish with average initial weight (+SEM) of 2.32±0.01 g/fish for 8 weeks. All dietary groups had 100% survival. No significant effects due to the different diets were observed in f ish responses including percent weight gain (WG), feed efficiency (FE), feed intake (FI), protein efficiency ratio (PER), condition factor (CF), and hepatosomatic index (HSI) (Table 1) . In fact, WG of fish fed the CFP3 0% diet was 15% higher than that of fish fed the Reference diet, suggesting that CFP improved juvenile tilapia growth performance and could completely replace SB M in the Reference diet .