A possible solution to the growing demand for quality protein is an increase in aquaculture. A downfall of aquaculture is that the fish in the aquaculture system often become very stressed due to overcrowding, poor water quality, constant handling, or transportation. This stress leads to a decrease in immune responses and their susceptibility to diseases. These diseases are then treated with chemical drugs. This leads to issues as chemicals may be released into the environment through watersheds or can leave traces in the fish that are then consumed by humans. The solution to this issue could be the use of nutraceuticals. Previous research, performed at our lab, have shown to modulate stress and immune responses in fish using different kinds of nutraceuticals. Currently, we are investing the effects of astaxanthin and tryptophan in tilapia, reared in recirculating aquaculture system and in aquaponics system. We will present our findings in the Aquaculture America 2024 conference.