Effects of five diets containing different ratos of sesame seed cake meal (SS) and sweet potato leaf meal (SP) mixture (10:5 or 15:5) to replace Fish meal (FM) was studied on growth and liver histology of Guppy (Poecilia reticulata). A total of 450 Guppy fry of averaging 0.06±0.01 g (1.84±0.11 cm) were randomly stocked in 125 L fiberglass tanks in triplicate groups of 30 fish. Diets having 30% (Control diet- CD), 15% (15FM), 10% (10FM) 8% (8FM) and 0% (0FM) of FM component and with varying levels of SS and SP mixture were fed to Guppy fry ad libitum 3 times daily for eight weeks period. At the end of growth trial, fish fed CD and 15 FM (10 SS:5 SP) diets exhibited significantly better growth performance compared to fish in other three treatments. %SGR and condition factor were ranged from 3.2 -4.0 and 1.27- 1.37 respectively. Fish in CD and 15FM treatments showed better growth performance and feed utilization without any negative effects on their survival compared to fish fed on other diets. Fish fed 8FM diets showed the highest whole body protein while fish fed 0FM diet showed the highest body lipid composition compared to other fish. Alternations in vacuolization in fish liver tissues were observed in various treatments. The cost benefit analysis of experimental diets indicated that FM replaced diets were economically superior compared to the control diet in which FM was the major protein source. However, comparing growth and feed utilization 15FM diet containing 10% Sesame seed cake meal and 5% Sweet potato leaf meal can be considered as the best option among the low cost diets tested for guppy reared in experimental conditions.