This study explores the transformative potential of Artemia (brine shrimp) as a human food source, positioning it as a cost-effective, nutrition-sensitive business model to address food, nutrition, and economic security in vulnerable and climate-affected regions. Traditionally used in aquaculture, Artemia is rich in high-quality protein (40–65%), essential omega-3 fatty acids (EPA and DHA), iron, zinc, and calcium, making it a sustainable solution to combat malnutrition, particularly during the critical first 1000 days of life. The study integrates desk reviews, expert consultations, nutritional calculations, and conceptual modeling to assess Artemia’s viability for human consumption, its scalability in saline environments, and its market potential. It highlights how Artemia-based products such as kebabs, omelets, and fortified powders can support maternal and child nutrition, generate women-led income opportunities, and create climate-resilient food systems. Despite promising nutritional and environmental profiles, the report identifies key challenges, including data gaps, consumer acceptance, regulatory frameworks, and supply chain development. To unlock Artemia’s full potential, the report recommends strategic investments in research, pilot programs, market development, and policy engagement. By advancing Artemia as a human food, stakeholders can simultaneously tackle pressing issues of protein scarcity, micronutrient deficiencies, poverty, and climate resilience making Artemia a promising innovation for global food and nutrition security.