Per- and Polyfluorinated Substances (PFAS) persist in marine environments through a variety of point and non-point sources. PFAS tend to persist in higher concentration in Atlantic Blue Crab tissue than the waters they inhabit. In the Maryland Coastal Bays (MCBs), Hematodinium perezi is a parasitic dinoflagellate that proliferates in the hemolymph of crabs, drastically impacting their survival. However, the relationship between high PFAS concentration and Hematodinium impacts have not been studied or connected. From the MCBs, 120 Blue Crabs samples were collected, and their tissue and hemolymph will be tested for PFAS levels and Hematodinium levels. Additionally, environmental parameters such as temperature, salinity, and water quality were also considered to evaluate potential associations with parasite prevalence and PFAS contamination. This study will provide valuable insights into the concurrent exposure of Atlantic Blue Crabs to parasitic infections and environmental contaminants in the MCBs. Thus, will contribute to our understanding of the ecological health of blue crab populations and inform management strategies aimed at conserving this economically important species. This is a current ongoing study, and results will be presented when analyzed.