The soft-shell clam (Mya arenaria) is an infaunal, filter-feeding bivalve native to coastal and estuarine habitats between Nova Scotia, Canada, and North Carolina, USA. Commercial-scale aquaculture and harvest of the species is limited to the northern portion of its range, yet there are benefits to growing soft-shell clams in warmer climates; cultured clams grown over the winter and spring in the Chesapeake Bay exceed growth rates of 1 mm shell length added per week and reach market size of 50 mm in under a year. Growth and survival of soft-shell clams, however, are negatively impacted by recruitment of predators and elevated water temperatures (> 28 °C) over the summer in Chesapeake Bay. This project investigated whether grower interventions (i.e. removing sediments and recruited predators from cages) could enhance soft-shell clam growth and survival during the summer grow-out season. Between 15 May 2024 and 17 July 2024, 90 soft-shell clam aquaculture cages with &fraq14;-inch flexible predator-deterrent mesh were deployed across three locations in the York River, VA. Clams were planted at a density of 1000 individuals per m2 (66 clams per cage), and cages were assigned one of 5 treatment groups: weekly or biweekly sediment removal; weekly or biweekly predator and competitor removal; and an undisturbed control. Planting location and temperature were significant predictors of soft shell clam survival, but treatment group had no significant impact on survival. Treatment group was a significant predictor of growth, with significantly smaller clams in cages handled more frequently than the less-handled and control cages, suggesting that cage disturbance is detrimental to the soft-shell clam grow-out cycle.