There is an increased need for development and implementation of nature-based solutions for improving coastal resilience in regions on the front lines of climate change impacts. South Florida has been identified as one of the most at-risk communities in the nation in the face of climate change, and Biscayne Bay is widely considered ground zero in its exposure to many of the most common coastal resilience challenges. While historical populations of native oysters (Crassostrea virginica) in Biscayne Bay have been decimated over the past decades, remnant populations remain in various portions of the Bay. Current restorative aquaculture activities centered at the University of Miami – Rosenstiel School aim to connect community partners, scientists, habitat restoration specialists, and conservation practitioners to build capacity in utilization of oyster restoration in Biscayne Bay for living shoreline initiatives. Additionally, research is underway in exploring the utilization of native Biscayne Bay oysters in land-based integrated multitrophic aquaculture (IMTA) systems to develop strategies for advancing marine aquaculture in the region through effective product diversification that may allow for improved environmental sustainability and economic viability. Leveraging expertise in restorative marine aquaculture, ecological genomics, outreach, and education, this project has the potential to play a critical role in coastal resilience initiatives throughout the region while providing valuable ecosystem services associated with native oyster restoration. Research activities on oyster aquaculture at the University of Miami – Rosenstiel School will be presented and discussed along with future directions of the project.