The production of macroalgae (“seaweeds”) within integrated multi-trophic aquaculture (IMTA) systems has many benefits for improving the environmental sustainability of marine finfish production ventures while offering opportunities for improved economic viability of such operations. Although IMTA seaweed production is well established globally in operations centered around production of temperate species of marine finfish, the techniques, technologies, and overall production strategies for seaweed species native to the Southeast U.S. and Caribbean within IMTA production systems is at a rather incipient stage in the U.S. In order for U.S. producers of seaweeds to be able to compete in an import dominated marketplace, there is a critical need for identifying strategies that allow for economically viable domestic seaweed production. Some of the keys to viability in the Southeast U.S. and Caribbean include identifying native seaweed species that have: 1) the greatest ability to utilize nutrients in marine finfish production effluent water: 2) the highest market value; 3) the post-harvest techniques, including value-add strategies, that will allow for highest economic returns for producers in the region. Results of research and development activities centered around IMTA production of native seaweed species of the Southeast U.S. and Caribbean region will be presented and discussed. Aspects of this work have been supported by the Gulf States Marine Fisheries Commission (GSMFC) and the National Oceanic and Atmospheric Administration (NOAA).