Marine aquaculture is a rapidly growing field both in technology and protected species monitoring and mitigation. In the U.S. Pacific Islands Region, the Hawaiian monk seal (Neomonachus schauinslandi) is an endangered endemic species whose range overlaps with an aquaculture facility using open-water finfish net pens. Aquaculture facilities can attract wildlife, including protected species, resulting in unwanted interactions. NOAA Fisheries has partnered with Blue Ocean Mariculture to investigate and adaptively manage monk seal interactions at its aquaculture facility following a 2017 mortality event and subsequent Endangered Species Act section 7 consultation. This is a coordinated effort between managers of the regulatory branch at NOAA’s Pacific Islands Regional Office, scientists at the Pacific Islands Fishery Science Center, and Blue Ocean Mariculture. To date, over 160 hours of camera footage and three years of human observations have been reviewed. Through the use of aquaculture personnel observations, deployed underwater HD cameras, and artificial intelligence, we can identify and analyze monk seal behaviors associated with the aquaculture net pens, which allows us to test mitigation strategies for minimizing the targeted behaviors. We have identified 71 distinct monk seal interactions and behaviors associated with the net pens that we aim to minimize. Our results show that when used together, human observation and cameras are an effective way to identify and monitor Hawaiian monk seal interactions at an offshore aquaculture facility. This data is being used to implement protocols and mitigation measures to deter Hawaiian monk seals from predating the pens and to reduce the probability of protected species injury or death. Outcomes of this ongoing project will provide a more detailed understanding of protected species behaviors around aquaculture net pens, support adaptive management, and the regulatory processes necessary to reduce these risks.