Mitigating Bolbophorus damnificus outbreaks in catfish aquaculture primarily consists of disrupting the parasite life cycle by targeting the snail intermediate hosts. Copper sulfate pentahydrate (CSP) is a common and effective molluscicide but can have adverse effects on pond and fish health. Previous studies have shown wild-caught snails to be more susceptible to CSP than lab-reared snails. This may be an indication of poor snail vigor from handling and transport, environmental stressors, or trematode parasitism. In this study, CSP toxicity was assessed in laboratory-reared Marsh Ramshorn snails Planorbella trivolvis and wild-caught individuals actively shedding trematode cercariae. Given the low prevalence of B. damnificus in snail populations (typically 1 - 5%), snails parasitized with a more common trematode, Alloglossidium kenti, served as a proxy for the effects of trematode parasitism on P. trivolvis exposed to CSP. Two trials were conducted, consisting of 4 weekly treatments of varying CSP concentrations. In both trials, survival curves and hazard analysis revealed that laboratory-reared snails were most resistant to CSP, followed by wild-caught non-shedding pond snails. Wild-caught snails actively shedding A. kenti cercariae were most sensitive to CSP treatment. Increased susceptibility of parasitized snails to lower CSP doses demonstrates a potential targeted approach selective against parasitized snails within catfish pond systems. Therefore, complete eradication of P. trivolvis from catfish ponds may not be necessary for effective trematode control, and lower doses than those previously reported may prove effective at mitigating trematode-associated losses in US catfish aquaculture.