Soybean meal (SBM) is one of the essential plant-protein sources in aquaculture feed. Several methods have been used to reduce oligosaccharides and other antinutrients to improve the quality of the SBM. In this work, we used low oligosaccharide (LO-SBM) and enzyme-treated soybean (ET-SBM) meals as the primary protein source; this study sought to assess the effects of varying replacement percentages of SBM with LO-SBM or ET-SBM on the growth and feed utilization efficiency of Pacific white shrimp. Nine isonitrogenous (35% protein) and isolpidic (8% lipid) diets were formulated. The basal diet utilized solvent-extracted soybean meal as the primary protein source and was incrementally replaced (40%,60%, 80%, and 100%) using LO-SBM or ET-SBM. Fifteen juvenile L. vannamei were stocked in each of the 44 indoor recirculating aquaculture system tanks. Diets were randomly assigned to five replicate tanks. The experiment was performed for 5 weeks, during which the shrimp were fed four times throughout the day, and the feed ration was adjusted on a weekly basis. At termination, shrimp were counted, and the group was weighed to assess survival, growth, and FCR. Subsequently, two shrimp guts were collected per tank of the basal, LO-SBM100%, and ET-SBM-100% treatments. The remaining shrimps from each tank were preserved and later analyzed for whole-body proximate composition. All growth metrics in the trial showed better performance or shrimp feed LO-SBM diets (p<0.05). Except for phosphorus retention (p<0.001), we observed no significant differences in whole-body proximate composition (p>0.05). The outcome showed the potential of replacing the solvent-extracted soybean meal with a new variety of low oligosaccharide and enzyme-treated meals when needed, as well as survival or feed conversion ratio (FCR). Additional results on gut microbiomes will be presented. Low oligosaccharides and enzyme-treated SBM supported good shrimp growth and are suitable protein sources