Despite forecasts of low prices and higher input costs, shrimp production is forecasted to increase, driven by contributions from India, Ecuador and Vietnam. The feed industry has been supporting shrimp farmers by working to reduce or stabilize price increases through the use of lower cost feed ingredients and improved formulations. For that reason, the implementation of cost-effective ingredients that assure growth and health has demanded more attention in the past few decades, with ethanol industry leading the development of new corn co-products, such as corn fermented protein with yeast (CFP50Y) Contain 50% crude protein and less fiber, this is an attractive protein source in feeds. The current study assesses the efficacy of CFP50Y on pacific white shrimp under pond conditions. Four isonitrogenous (35%) and isolipidic (8%) extruded diets were formulated to partially reduce soybean meal as the inclusion of CFP50Y increase (0,5,10 and 20%). The pond trial was conducted in 16 ponds (0.1 ha) stocked at 0.032 g and 25 shrimp/m2, over 82 day of culture period. The feed was delivered using passive acoustic feeders from AQ1. At the conclusion of the pond trial, whole body analysis revealed a significant increment in phosphorous retention at 20% of inclusion of CFP50Y, (P=0.009). There were no significant differences(P>0.05) in shrimp production across the dietary treatments. However, the feed cost was significantly lower at the highest inclusion level of CFP50Y.These results indicate that CFP50Y can be used up to 20% without adverse effects in growth performance of Litopenaeus vannamei.