Marine-integrated aquaculture recirculating systems hold immense potential to resolve food, energy, and water dilemmas on a global scale. Recirculating aquaculture systems help to conserve water; however, significant energy, cost, and environmental savings may be obtained by trying different biofilters. For instance, periphyton (the slimy coat of algae and bacteria that grows on surfaces) biofilters demonstrate their ability to save energy and recover nutrient resources. This study delves into the testing of different aquaculture biofilter combinations such as periphyton with halophytes (H+P), periphyton with moving bed biofilm reactors (P+M), and periphyton only (P2). Two pilot-scale RAS (2500L/RAS) were utilized at a red drum stocking density of 14-18 kg/m3 (Figure 1). The experiment was run in two trials (spring and summer) for four replicates. Fish mortalities were low, with the food conversion ratio between 1.1 and 2.0. All trials maintained NO2-, NO3-, and CO2 below toxic limits. The P2 trials maintained a stable alkalinity and pH balance; however, the M+P and H+P systems required an alkalinity addition of 100-200 CaCO3 mg/L per trial. Periphyton in all trials added DO to the water (at an average of +3.95 ± 6.52 mg/(L*d)), thus adding energy savings. The M+P trials removed NH3/NH4+ at a higher rate; however, they also operated at higher energy and required more DO. Seasonal effects of spring and summer were found to influence several parameters including the periphyton growth rate, pH, ammonia concentration, and DO concentration. All systems recovered nutrients, although the H+P and P2 had the highest recovery rate. Periphyton was found to include valuable lipid content (4.55 ± 2.24 % of dry weight) with the detection of Ω-3 fatty acids. The H+P system produced periphyton for aquaculture use and halophytes for human food. Sea purslane growth rates (1.0431 ± 0.3361 g/day/plant) were high in all trials. The microbiome revealed denitrifiers, ammonia-oxidizing microbes, nitrite-oxidizing microbes, and valuable algae such as Chlorella.