Shrimp aquaculture is progressively adopting innovation to increase productivity of farm systems and lower risk due to disease and environmental perturbations. Cutting-edge technologies based on artificial intelligence (AI) , rapid and farm -scale disease diagnostics, elucidating role of microbiomes, and the integration of advanced genomic approaches into breeding programs, converge to address critical challenges in shrimp aquaculture and allow for the first-time precise information on the genetic performance, health and well-being of farmed shrimp . Whilst many of these innovations are not yet fully implemented into commercial practice, they have defined new areas and opportunities to resolve the hidden forms of variance that are inherent in shrimp farming, ultimately leading to informed and more proactive management decisions. This presentation will focus on several of these innovative technologies (AI/ machine learning, genomic prediction, microbiomes and environmental DNA) and how by harnessing these tools we can optimize breeding, disease management, and sustainability of shrimp farming.