The present study was carried out to evaluate the ability to use Pawpaw seeds powder as a natural reproductive inhibitor for three spotted bream (Oreochromis andersonaii) to control their propagation. The experiment was divided into two treatments T1 and T2 and a commercial feed, both T1 and T2 replicated twice each; the first was treatment one (T1) during which the O. andersonaii were treated with Pawpaw seeds powder 5g for 45 days and the second was the T2 whereas the O. andersonaii was treated with 4g of Pawpaw seeds powder. The juveniles were obtained from the ponds and graded according to sex manually, the males and the females were close to the sexual maturation or breeding stage. The male juvenile fish and female juvenile fish were placed in different ponds to prevent early breeding before they were fed different levels of Pawpaw seeds powder. This was done to avoid biases in the results. The Pawpaw seeds powder was added to the fish meal diet at different levels of 4g and 5g/kg diet for 45 days. According to the observation of this study, the result shows that. Also, the high levels of Pawpaw seeds powder (5 g / kg diet) caused obvious histological alternations of the testes and ovaries of O. andersonii which reduce the fertility of both males and females. Consequently, it could be recommended that the effective use of Pawpaw seeds powder as a natural reproductive inhibitor for O. andersonii.
Keywords: Growth, survival, Carica papaya, Oreochromis andersonii.