As antimicrobial resistance to conventional antibiotics has become prominent, it is crucial to look for effective antimicrobial agents in natural resources. Among all resources, marine environment is one of the potential resources to explore as it is the hub of various natural bioactive compounds. To this end, we performed research in Luidia clatharata (slender armed sea star), richly endowed species with bioactive potentials. Specifically, the goal of this research is to investigate the antimicrobial activity of L. clatharata against the selected five gram-negative and five gram-positive bacteria. The result obtained from the experimentation demonstrates that the crude extract of the body wall with ethyl acetate exhibits impressive inhibitory ability against the tested pathogens. This diffusion ability signals that L. clatharata could serve as an important natural resource for nutraceuticals. For this, a detailed study is required to identify and understand the active compound responsible for this inhibitory effect. The detailed findings will be discussed at the conference.