In line with sustainable development goals, the combination of biological, chemistry and physics are fundamental science to be revisited in aquaculture. Fundamental science coupled with new technologies such as artificial intelligence, engineering and computational biology which are essential core components to ensure aquaculture growth in the ASEAN region. The multidisciplinary approach makes an important contribution to ensure safe and healthy food for the people. Thus, the innovation and disruptive technologies demonstrated in our study which will give solutions to the aquaculture growth and its environment. Food security and safety and its nutrition benefits with the aid of next generation approaches will pave way to ensure sustainable production in the years to come. In this paper, we will discuss case examples of how next generation approaches are used in biosafety and biosecurity area, host, pathogen and environment interactions and food security and safety. Innovation approaches discussed can be short to long term approaches in sustainable aquatic production.