Singapore is a small island country with limited land and sea space for agriculture and aquaculture. Foofish aquaculture production in Singapore is mainly from cage aquaculture in sea and supplied about 10% of total fish consumed. The major cultured species are Asian seabass, red snapper, golden pompanos, hybrid groupers and shrimps. Although small scale of its aquaculture, constrained by limited available land and coastal areas and high cost for aquaculture, the industry is thriving and transferring from low-tech to high-tech. With the strong support of the government for food security, aquaculture research and development are geared towards developing novel hatchery technologies, marker-assisted and genomic selection to accelerate genetic improvement, the establishment of high-tech aquaculture farms and ensuring biosecurity. In this paper, I will summarize the status of Singapore’s aquaculture and its challenges and discussed the future directions. I will also talk about some details on the breeding program for the genetic improvement of Asian seabass. Using conventional breeding approaches, marker-assisted selection and genomic selection for three generations, we have substantially improved growth (> 45%), disease resistance against big belly, nodavirus and iridovirus (no breakout in our hatchery), and omega-3 contents (> 700 mg/100 g meat). We have established three elite lines, one for growth, the second for disease resistance and the third for higher omega-3 contents. Superior hybrid fingerlings have been supplied to local farms and neighbouring countries for commercial production.