This paper focused on infectious diseases among fish in South Sudan aquaculture and their impact on fish and human life, as well as the various interventions that have been used to prevent and control these diseases. Regardless of the culture system used, it is imperative that the culturist maintains an environment conductive to good fish health. However, fish farming conditions are often conducive to the spread of disease. The objectives of control measures for infectious diseases are to:
Important fish disease in fresh water and disease cause by Aeromonas hydrophila is also Known as motile Aeromonas Septicemia, therefore the clinical sign can cause the dropsy Asciles/Fluid and also can cause serious damage in internal organ, also damage in Kidney. As can be seen from the above review, bacteria are responsible for many diseases and heavy mortality in cultured fish. Pathogen isolated in characters of Aeromonas hydrophila incubating on gram negative and gram positive.