Disease is a natural trait of life. Relatively little research has been done on the disease in wild aquatic animals. This article focuses primarily on cultivated animals. Aquatic animals are specifically associated with the main groups cultivated around the world: Mollusks, crustaceans, and fish. Whether the pathogen causes the diseaseĀ depends on it Not only from the pathogenicity of the pathogen, but also from the immune system of the infected animal. Both sides of this relationship are influenced by the environmental conditions and stressors that can impair the immune system. It disrupts the interaction between the host and the pathogen, causing illness. Currently known, it outlines the immune mechanisms of mollusks, crustaceans, and fish. Approach to Disease prevention, diagnosis, and management are some of the technologies under development and future requirements.