Aquaculture Africa 2021

March 25 - 28, 2022

Alexandria, Egypt

DETECTION OF FUNCTIONAL SNP MARKERS IN RAINBOW TROUT Onchorhynchus mykiss FROM NEXT GENERATION SEQUENCING (NGS) DATA

Sajad Nazari*1; Saltanat Najjar Lashgari2; Mahdi Golshan3

 

1Shahid Motahary Cold-water Fishes Genetic and Breeding Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Yasouj, Iran

2Cold-water Fishes Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tonekabon, Iran

3Iranian Fisheries Sciences Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran

*corresponding e-mail:sajadnazari13@gmail.com

 



Rainbow trout (Onchorhynchus mykiss)  is one of the most important freshwater aquaculture fish in Iran. It is necessary to development available molecular marker associated with genetic variation in  maturation for O. mykiss.  In this study, 52 novel SNP markers for O. mykiss were discovered for functional markers,  and validated based on transcriptome sequencing with the Illumina Hiseq2500 platform and most of variants cause synonymous mutations in protein . The observed and expected heterozygosities ranged from  0.177 to 1.000  and 0.239 to 0.638 , respectively.  The  minimum allele frequency (MAF) ranged from 0.166 to 0.489.  Among these SNP loci,  twenty two loci showed significant  departures  from the Hardy–Weinberg equilibrium after Bonferroni correction ( < 0.05)  and significant linkage disequilibrium was found.  These data provide valuable transcript sequence and functional marker resources for the quantitative trait locus (QTL) identification.  The  SNP  markers would be used in genetic studies helping economic performance  improvement and  management of this species.

 Keywords: Single nucleotide polymorphism (SNP); Rainbow trout; Next generation sequencing; RNA-seq