Physicochemical properties play essential roles in the maintenance of healthy aquatic ecosystem. The need for water quality monitoring is paramount to safeguard the public health and also to protect the water resource in Nigeria. Hence, this study aimed at assessing the physicochemical parameters and fish composition of Ogbese River in Ogbese, Ondo state, Nigeria. A total of sixteen samples were collected fortnightly, during the months of February to April, 2021. The values obtained for the physicochemical parameters such temperature, alkalinity, pH, total hardness, phosphate, sulphate, DO, BOD, COD and others were 23.56±2.03, 96.82±101.41. 7.47±0.44, 105.25±26.65, 18.39±3.67, 15.66±6.45, 5.18±1.70, 2.56±0.59, 4.00±1.39 respectively. They are all within the range of values recommended by WHO, NIS and FEPA with the exception of dissolved oxygen, phosphate and nitrate. All the assessed parameters were statistically significant (P <0.05) with the exception of hardness and nitrate . Furthermore, a total of two hundred and sixty-two fishes of seven (262) different species were obtained from Ogbese river in Ondo state. The species of fishes caught are; Clarias gariepinus , Heterobranchus bidorsalis , Oreochromis niloticus , Tilapia zilli , Parachanna obscura, Malapterurus electricus , and Hepsetus odoe . Among the fish species, Clarias gariepinus have the highest population abundance (34 %) while the least species of fish obtained was Hepsetus odoe (2%). In conclusion, Ogbese River is of good quality, fit for domestic and agricultural purposes except for the excessive lead, phosphate, nitrate and dissolved oxygen content. However, further study is recommended on the source and quantification of heavy metals present in Ogbese River for timely intervention to public health advantage.