Sea cucumbers are known to be utilized as a source of traditional medication and nutrition in Asian countries. Several species have been researched for their potential source of therapeutic al properties. It is known that compounds such as carotenoids, triterpene glycosides, bioactive peptides, minerals, vitamins, fatty acids, chondroitin sulfates, collagens, gelatins, and amino acids are present in these invertebrates. Through scientific research, medicinal benefits of some species of sea cucumbers have also been affirmed. We are, therefore, investigating the physiological, immunological, and microbiological effects of several species of sea cucumbers in-vitro , found in the waters of the United States of America. Results obtained from these investigations will be presented in the upcoming meeting of the World Aquaculture Society.