Aquaponics, the integrated production of fish and plants, has gained attention and international interest. This system uses nutrient-rich effluent from the fish system as a fertilizer for plant production. While aquaponic set-ups vary greatly, the goal of commercial operations is profitability. Target markets for product are variable, depending on location, seasonality, and species or cultivars produced. Technological advances in aquaculture and horticulture continue to aid the development of the industry, but economic analysis remains scarce. This study investigated the current profitability and potential of a decoupled aquaponics operation, using one fish greenhouse stocked with tilapia, and one plant greenhouse producing cucumbers in a pilot-scale aquaponics system at the E.W. Shell Fisheries Center (Auburn, AL). Q uantities of production inputs required for crops of tilapia (Oreochromis niloticus ) and cucumbers (Cucumis sativus L. 'Delta Star') and quantities sold of each product were transformed into dollar amounts and entered into 12 monthly cash flows . Enterprise budgets were developed from the cash flow, augmented with fixed costs calculated from the initial investment schedule to obtain net returns to owner's labor and management. Research production of cucumbers was 5,544 kg of cucumbers after extrapolation to the full greenhouse area. Tilapia production was 3,002 kg and not expanded. A two-way s ensitivity analysis indicated a tilapia price of $3.00/lb and a cucumber price of $2.00/lb was required to breakeven, covering variable plus fixed cost. Prior research had shown nutrient effluent s coming from one tilapia green house was sufficient to supply fertilizer for four cucumber greenhouses. R esearch results were extrapolated to four cucumber greenhouses fertilized by the one tilapia greenhouse . Total investment was $303,152. Tilapia returns were positive/negative in the short/long run. However, including cucumbers resulted in positive overall returns, Table 1. The cost of production covering all costs was $3.27/lb and $1.48/lb for tilapia and cucumbers respectively . Aquaponic tilapia- cucumber systems can be profitable, but rely heavily on market selling prices, quantity produced, and scale of operation.