PROTEOMIC META-ANALYSIS OF Macrobrachium tenellum

The prawn Macrobrachium tenellum possesses a strong potential for aquaculture due biological characteristics, despite this, there are only few studies related to biochemical characteristics of metabolism in this specie, were proteome studies has been limited, but with the possibility of understanding of metabolic pathways, protein association, metabolic clusters, and biological function.

In this research we report the first meta-analysis of the proteome from prawn M. tenellum using all online-publically available protein sequences (or gene), we use the Gene Ontology Term obtained for each protein using the UniProt accession on the GoRetriever tool of AgBase; and all the GO Terms were classified (GoSlim2) using CateGOrizer tool of the Animal Genome Research Program on Cellular Component, Molecular Function, and Biological Process. P-value was used as control in all

We found 374 differential proteins reported from M. tenellum, with 13286 GO terms.  Principal Biological function was for cellular metabolic process specifically, generation of precursor metabolites and energy, conducted by respiratory electron chain transport (ECT). The metabolic process was conducted by oxidation-process linked to ECT, meanwhile localization of those process was in membrane transport inorganic ions (transmembrane) related to proton transmembrane transport. The molecular functions were meanly related to transporter activity to the ECT by proton transport. Cellular components were meanly to organelle inner membrane, specifically mitochondrial inner membrane.

Immune system, and lipid metabolic, besides cation transport was the by uniqueness the most important process developed in the cell. Toll signaling pathways mediated by MyD88, MAPK cascade, and signal transduction by G-coupled proteins was the most relevant pathways identified by proteome analysis.

Present reports could guide the next immunological or metabolic research to develop more information regardless the biological context of M. tenellum culture.