Practical formulation of high value feeds with no or low fishmeal requires commercial accessibility to ingredients containing high levels of digestible protein and nutritional supplements that can fill the gap in nutrient specifications of the feed when fishmeal is removed. The ingredients need to be extensively characterized with respect to nutrient content and digestibility so that a reliable matrix can be developed in the formulation program. Establishing the effect of the ingredient on animal performance based on long-term feeding trials will be helpful for the feed manufacturer to set minimum and maximum levels of the ingredient in the program. Critical gaps to fill in the nutrient and functional specifications of the feed when fishmeal is removed are amino acid balance, highly unsaturated fatty acids, cholesterol and attractants and palatability enhancers. Suppliers of the nutritional supplements need to consider concentration of active principles, cost, dosage and application methods when offering a solution. In the area of attractants and palatability enhancers, ingredients such as krill and marine protein hydrolysates that can be added at low inclusion levels provide flexibility for the feed manufacturer to choose a wide variety of macro ingredients to meet protein and energy requirements.