Triphenyl phosphate (TPP) is a phosphate ester flame retardant product, widely used as Plasticizer. TPP induced toxicity response in tissues of Indian major carp, Catla catla has been reported. Histological observations confronted detrimental morphological and anatomical alterations induced in vital organs like gill, muscle, liver, intestine, stomach and kidney by sub - lethal toxicity of TPP. Histological studies revealed that the tissue impairment were found to be adverse with increase in concentration (0.25mg/gm < 0.5 mg/gm < 1 mg/gm) and exposure duration (0 - 15days) of TPP. As a conclusion, the findings of the present histological investigations demonstrates that the exposure of fresh water teleost fish, Catla catla to varying concentration of TPP caused moderate to adverse tissue impairment in vital organs. Hence, this plasticizer, TPP should be used in low ratio for its toxic effect.