The present experiment was conducted to study the effect of multiple stressors on growth and IGF-I gene expression without and with dietary zinc, selenium, vitamin E and methionine based nutraceutical in Labeo rohita fingerlings. One thousand and eighty (1080) acclimated rohu fingerlings with an average size of 8.5 ± 0.5 g were randomly distributed in 6 distinct experimental groups in triplicate, where first three groups were exposed to high stocking density (HSD; 20 nos / 75 L water) with restricted feeding (RF) and second three groups were exposed to normal stocking density (NSD; 10 nos /75L water) with satiation feeding (SF). Nutraceuticals were fed to both stress exposed and unexposed groups at 0, 0.1 or 0.5% levels. Hence, the six experimental groups were designated as THR0 (HSD, RF, 0% nutraceutical), THR1 (HSD, RF, 0.1% nutraceutical), THR5 (HSD, RF, 0.5% nutraceutical), TNS0 (NSD, SF, 0% nutraceutical), TNS1 (NSD, SF, 0.1% nutraceutical) and TNS5 (NSD, SF, 0.5% nutraceutical). Monthly sampling was done during four months experimental period. The weight gain (WG) %, specific growth rate (SGR), protein efficiency ratio (PER) and IGF-1 expression were significantly lower and feed conversion ratio (FCR) was significantly higher in fish of HSD with RF at the end of every month of the experiment. However, dietary nutraceutical could not recover these changes up to the level in fish of NSD with SF. Although dietary nutraceutical supplementation did not significantly change WG%, FCR and IGF-I expression in fish of NSD with SF, the fish of HSD with RF exhibited significantly higher WG% and IGF-I expression and lower FCR due to nutraceutical supplementation at the end of every month of the experiment. But fish of TNS1 exhibited significantly higher PER at the end of third month and the fish of TNS5 showed significantly lower SGR at the end of third and fourth month of the experiment. Dietary nutraceutical did not change PER at the end of third month and SGR at the end of second and third month of the experiment. Further, two way ANOVA revealed that 0.1% dietary nutraceutical resulted significantly higher WG% at the end of third and fourth month, PER at the end of third month, SGR at the end of first month and IGF-I expression at the end of first and fourth of the experiment in the fish of HSD with RF. Hence, the present study concluded that the stress exposure in terms of higher stocking density and restricted feeding reduced the growth in fish but mineral and vitamin based nutraceutical supplementation cannot recover this up to the level of stress unexposed fish. Among the stress exposed groups, the Labeo rohita fed 0.1% nutraceutical could exhibit higher growth at the end of third and fourth month of the experiment.