Feasibility studies on the cage culture of orange spotted grouper, Epinephelus coioides was undertaken in 6m dia. GI cage in the marine farm at Karwar and studied the growth performance in marine waters of west coast, India. Nursery reared groupers were stocked in 6 m dia. steel cage with an initial biomass of 0.2 kg m-3. Growth and environmental parameters were monitored at regular intervals for a period of 300 days. The study revealed a high growth rate and attained an average marketable size of 0.5 kg in 6 months culture period. The final biomass at 300 days of culture was 8.5 kg m-3. The study indicated that the Epinephelus coioides is a potential mariculture species for cage farming along west coast of India.